I have seen quite a number of 750 barrels over the years where the flange either showed a crack or had parted company with the barrel. Not sure if all of these were bored oversize, which will obviously weaken them, but nearly all of these were off normal road bikes, not racers.
On my race bike I use one of the barrels that look like 850s (i.e. with through bolts), but are to 750 spec (part# 06-1705)- remember the head bolts are also in slightly different positions on 750s to 850s. These barrels are about to be available again from Andover Norton- should be finished within this month, together with the new batch of 850s (part# 06-5074).
Another pro- at least for racing- is, that the more solid barrel, bolted to the naturally fragile crankcases, acts like a "stiffening kit" for the crankcases, which is a good thing especially in a race engine developing a lot more horses and torque than a road engine. Then again, it doesn't hurt on a road engine, either!
Joe Seifert