How fast a Commando goes in top gear depends in where the motor has to come from. If you have 5 gears and the top 4 are close, when you change from 4th to 5th, you don't lose many revs. Also, you might have the needle set right for high vacuum conditions, but when you change up, you back-off to take the load off the transmission. As you wind the throttle on again, you are into low vacuum again, and the needles in the carbs richen the mixture. If the taper is too quick or the port is too small, the mixture could be richer then the optimum. It does not take much to take the edge off the motor.
I use methanol fuel, so I have slightly more margin for error than I would have with petrol, but even with that - the slightest bit too rich causes the motor to respond slower.
With the Commando engine, I have found that if I gain an improvement, it usually does not become evident until I raise the overall gearing, and the bike gets to the next corner quicker.
There is a part of Winton Raceway which I know very well. The corner at the end of it is more than 90 degrees. If I get down the straight before it faster, that corner becomes more difficult. I use 6D Mikuni needles in a 34mm Mk2 Amals - the slowest taper. It means my jetting stays lean right down the needles as the throttle opens.
I do not use Amal needles and just accept that they are right at all throttle openings. With Mikuni needles you have a sensible needle chart. 6D suits both 32mm and 34mm Amal and Mikuni carbs. 6D is slow taper and 6F is quick taper. The 5 series is for the next two smaller size carbs.
Amal classification of needles is not so simple.
The taper on the needle might be different for bigger ports, but the type of fuel being used does not matter. The taper is there to compensate for loss of vacuum, and with a road bike, it does not matter so much, if it richens a bit too quick, as you open the throttle.
If my needle jets are half a thou of an inch too big, the bike becomes significantly slower, and that is with methanol - petrol is worse.
Modern bikes have fuel injection and probably better mixture and ignition control.