It makes a lot of sense to do this if you're looking for a race bike where Nourish aren't allowed (plenty of those here) or a hot rod road bike on a budget.
A Norton crank needs some mods to fit, I've forgot the precise details, but its quite easy for a competent tuner. A lightweight Maney crank would be an ideal starting point!
If you use Norton rods, and T140 pistons and barrels, the piston deck height all lines up perfectly.
As with Nortons, a big motor allows you to run a big cam, so Spitfire profile inlets and exhaust are the order of the day.
This makes for a really good, torquey, fast engine that is awesome on the road. I raced this set up in a few variations of Triton and ended up putting the last one on the road. I had the crank dynamically balanced to 80% and it was a really smooth bike (relatively speaking).
All in all, highly recommended IMHO.