If the bike ran fine for 200 miles, I can't see that there is anything wrong with the tune of the carbies.
However, when you went to reserve, the problem started.
I think I would be removing the tank, lines, carbies, air filter, etc.,
and cleaning everything. Is it by chance a Fibreglass tank, or a rusty Steel.?
Do you run a fuel filter on each line, it might be time for new ones.
Clean that carby out meticulously, especialy the, Starter Air Inlet which is at 3 o'clock looking from the rear, and
the two tiny holes in the bottom rear of the inside of the carby where the bottom of the slide would sit if it wasn't Cutaway.
They are part of the cold start system, if they are blocked they won't work.
This should get it starting and idleing properly again if it used to be allright.
The main issue is that it seems to lean out when you have been riding a while and I think it is a problem caused by
a restriction of some sort, that could start at the Taps (petcocks) or any where below them.
If you have a restriction to fuel flow, then turning the Air mix screw might help, but it will probably push the problem
on to somewhere else.
If it used to run well, go back to those settings after you have cleaned everything up... And start again.
Mikuni's don't change once they are right, they will also run on different settings as to another similar engine.
The mixture will lean off as the Air screw is turned out (anti clockwise). Richer... clockwise.
It's all good fun...
AC.