My experiences with gearboxes in performance situations started with a stock Commando 4-speed box on my first race bike. I didn't know any different, and rode around for a couple of years picking up speed and working on my race-craft. Then I was allowed to practice on a buddy's bike with a 5-speed box, and it broke my world wide open. In fact, this guy sold me this gearbox (Quaife) so he could buy a TTI box. My first time out with the Quaife on my own bike was eye-opening. it felt like I had a turbo boost when shifting into 3rd and 4th. I'd never before experienced keeping a motor in the power like that. The Quaife did have an overly-tall 1st gear (IOM style), which was not necessary for me as I never shift down to 1st in any race after my launch. I ran the Quaife for 2 seasons, but after sitting out of race weekends a couple of times with broken gears, I decided to sell it and put the money towards a TT box. I conferred with Mr. Shrapnel at the time, as he had a TT box on his 750 Short Stroke. And after long discussions with Bruce Verdon (a Hell of a guy, by the way) at TT Industries, we put together a really good box with the proper ratios to suit our races here in the US - short circuit, 8-10 laps. My first gear is just a little taller than a stock street Commando - great for launching, and the other ratios are nicely matched all the way up to 5. These boxes are bullet-proof, and shift so smooth, I actually had to put more pressure on the detent as it was too easy.
I have the luxury of running a Summerfield Manx and Seeley G50 on occasions, and they both have 6-speed TTI (Or Hemmings/Quaife drum-style) boxes, which are better suited to the way these bikes are ridden. Personally, with all the torque the conventional stroke Commando has, I would stay with the 5-speed if I had to buy another. Now if I had a tightly wound 750 short-stroke, perhaps a 6 would be the way, as Mr. Shrapnel has opined.
I have since raced bikes with stock street boxes on them, and I have to say, I've been spoiled. The downshifting on a street box in a race is so difficult, as every shift spins the motor so high, locks the rear wheel, and the duration it takes get down a couple of gears is a lap-time killer.
And finally, if I had the option, I would love to put a 4-speed close ratio cluster on a street bike. I know RGM has this option. That would be the best way to out-wring those corner cripples, Stevie Hobot.