My Seeley runs on methanol, but to get it right is just as difficult as with petrol. The motor is fitted with 34mm Mk2 Amals in which I use my own home made needle jets and Mikuni 6DP6 needles. The hardest part of getting the carburation right lies in the combination of needle and needle jet at 3/4 throttle. If the combination is too lean, the metering will be on that rather than the main jet,when the throttle is wide open. The first thing to do is to use the bigger main jets then lower the needles until the motor coughs when you are riding it around twisty roads. Once you have established that combination, raise the needles one notch and the bike should accelerate cleanly and swiftly right through the whole range of throttle openings. Mikuni needles are ground with three tapers, and using them you can get the tuning right, the amal needles tend to be a bit more crude. After you have the tuning right at 3/4 throttle, and through the rest of the range, it is then easy to get the main jets right by reading the plugs after a high speed blast on a long slightly uphill road. Your plugs on a road bike should have a 2mm black ring on the porcelain right down where it meets the metal. If it disappears you could burn pistons. It is possible that the metering never comes onto the main jet if your needles and needle jets are too lean, so if you fit the bigger main jets the motor should slow slightly in top speed, and the plugs should get darker. If this doesn't happen, you have a problem. In all of this, lean is good but always remember your bike will go its fastest just before it self-destructs. It is worth reading the Mikuni information on getting the tuning right . Most of it is about two strokes which are much more critical.
If you can get the carburation really lean right down the needle, and the main jets still work and are optimised, you will find that the bike really performs, and is lovely to ride until the weather turns really cold or hot. When you start it from cold, it should need the choke, and should spit and cough a bit, but be OK once it has warmed up. Most of your riding should not involve using the main jets, it will be on the needles and needle jets. On my own bike, the mains are rich and it does not matter - better to be safe than sorry.