I believe the second number is the aspect ratio (percentage) of the width (110mm here)
So... the 110-80 will have a smaller rolling diameter (0.9 x 110 minus 0.8 x 110 = 99 minus 88 = 11mm smaller diameter)
Probably doesn't matter on the front but will throw your speedo out on the rear.
Someone will correct me if I'm wrong.
Cheers
Rob