Interesting about what Johnm said about the Manx 16 gauge frames being less stiff than 14 gauge. A 16 Gauge straight tube length for length would be less stiff than it's 14 gauge counterpart.
The motorcycle chassis is so much more complicated than a straight tube though.
The main path on a featherbed frame from the swingarm up to the steering head has as much or more to do with the engine/gearbox unit and their engine plates as the frame itself, and figures into overall stiffness just as much also. Then there is the variation in the bends between a manx, road and slimline featherbed frames.
The Manx frame had a bit shorter tubes running on the top from the swingarm gusset up to the steering head, which would change it's stiffness over the road frame. Also the Manx frame being made of high tensile steel, though not changing the modulus of elasticity some harp about endlessly, would certainly change some handling quality just as a spring made of the two different materials would act differently?
The Manx had alloy engine plates, which may in fact have hurt it's stiffness over the steel ones used by the road bike, again hard to say because the plates were different shapes to fit different engines, but aluminum is much less stiff than aluminum size for size, and although the Manx plates were thicker than the road plates they were probably not enough thicker to be of any advantage in stiffness or weight, and coupled with their expansion which could push the chassis out of alignment and screw with primary chain adjustment they may have been more of a concession to style and trends than any advantage.
The slimline frame with it's longer-yet top tubes with extra bends connecting the swing-arm gussets to the steering head may indeed have been the least stiff of all if tested as a bare item devoid of all other components.
The Manx engine being taller and with a different head steady, along with it's standard metal swingarm mounts, was a motorcycle different enough in design to have a noticeable difference in handling.
In fact for mortals using the bikes as they are most commonly used, there will be no difference at all. And since top-tier Gp riders even back in the day never switched between the different types of featherbeds daily, weekly or even yearly, and since no engineer has ever completely computer-modeled the different featherbed bikes and frames, my opinions and anyone else's are just opinions.
True, some opinions may be from those who are more sane and better educated on the subject than others, but since all will make the claim that theirs is best and/or will choose the one which suits only their ideals, the only wise men here are those who know they are only here for specific information or entertainment......