For testing the main jet(s): find a road where you can pin the throttle in third or fourth gear, 10 seconds should be sufficient, Interstates are good for this. Once the engine responds, gets the bit in it's teeth and starts pulling, abruptly shut the throttle, if the motorcycle briefly surges forward with a burst of power your mains are too small.
If the motorcycle simply shuts down your main(s) are either just right or a tad rich. At this point a plug chop may help you decide. You can go the next smaller main(s), but be careful. A chassis dyno with EGA is, hands down, the best way to tune, but in the Mikuni tuning thread Full Auto posted a note about employing a wide band O2 sensor which sounds like it would pay greater dividends over the long haul.
Best